Driving
Lexington to Knoxville
Updated: 28 May 2026
The drive from Lexington to Knoxville covers 270 kilometers. You will head south on I-75. This route takes you through the heart of Kentucky and into Tennessee. The drive typically takes 2 hours and 45 minutes. Knoxville is a historic city known for its proximity to the Great Smoky Mountains.
Total Distance: 270 km driving distance; 230 km straight-line air distance.
Fastest Way
Driving via I-75 is the fastest way, taking 2 hours 45 minutes.
Cheapest Way
Driving your own vehicle is the most economical way to travel.
Compare Lexington to Knoxville Routes
Driving
Direct
Duration
2 hours 45 mins
Avg Price
$30-$50 in fuel
Operator
Personal Vehicle
Route
I-75 South.
Traffic in Knoxville can be heavy during rush hour.
Travel Tips
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TrafficAvoid rush hour in Knoxville to save time.
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FuelGas is readily available along I-75.
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NavigationUse a GPS to navigate the highway interchanges.
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ComfortBring a travel pillow and snacks for the drive.
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SnacksPlenty of options along the route.
Safety Tips
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SpeedingWatch for speed traps on I-75.
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FatigueTake regular breaks to stay alert on the long highway stretches.
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WeatherCheck for rain or fog in the morning.
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Emergency KitKeep a basic emergency kit in your car.
People Also Ask
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Is Knoxville worth visiting?Yes, it has a vibrant culture.
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How long is the drive?The drive takes about 2 hours and 45 minutes.
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Is there a train?No, there is no passenger rail service to Knoxville.
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What is the best route?The most direct route is via I-75.
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Are there tolls?No, there are no tolls on this route.
Quick Info
- From Lexington, Kentucky, United States
- To Knoxville, Tennessee, United States
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Modes
Best Time to Travel
Spring and autumn for the best weather.
Things to Do in Knoxville
1
Market Square
Explore the historic downtown area.
2
Sunsphere
See the iconic structure from the 1982 World's Fair.
3
Ijams Nature Center
Enjoy the nature trails.
4
Knoxville Museum of Art
Explore the art collection.
Tags
Lexington to Knoxville drive
travel to Knoxville
I-75 route
driving Kentucky to Tennessee
Knoxville travel guide
Lexington transport
fastest route to Knoxville
Southern travel
