Sumter
Sumter
Knoxville
Knoxville
Driving

Sumter to Knoxville

Updated: 28 May 2026

The journey from Sumter to Knoxville covers approximately 450 kilometers. Driving via I-26 West and I-40 West is the most direct route, taking about 4.5 hours. This route takes you through the beautiful Appalachian Mountains. Knoxville is known for its vibrant downtown and proximity to the Great Smoky Mountains.

Total Distance: Driving distance 450 km, straight-line air distance 350 km.
Fastest Way
Driving via I-26 and I-40 is the fastest method, taking 4.5 hours.
Cheapest Way
Driving is the most economical choice for most travelers.
Compare Sumter to Knoxville Routes
Driving
Direct
Duration
4 hours 30 mins
Avg Price
$50 - $80 in fuel
Operator
Personal Vehicle
Route
I-26 W to I-40 W.

Be prepared for winding roads in the mountains.

Travel Tips
  • Traffic
    Avoid Knoxville rush hour traffic on I-40.
  • Parking
    Use parking garages in downtown Knoxville.
  • Rest Stops
    Stop in Asheville for a variety of food and rest options.
  • Weather
    Be prepared for mountain weather changes.
  • Navigation
    Use a GPS to navigate through the mountains.
Safety Tips
  • Speed Limits
    Watch for speed limits in mountain passes.
  • Road Conditions
    Be cautious of fog in the mountains.
  • Vehicle Safety
    Check your brakes before driving through the mountains.
  • Emergency Contacts
    Keep a list of emergency numbers for your route.
People Also Ask
  • Is there a direct train?
    No, there is no direct train service to Knoxville.
  • How long is the drive?
    The drive takes about 4.5 hours under normal conditions.
  • What is the best time to leave?
    Leaving early in the morning helps avoid traffic.
  • Are there tolls?
    There are no major tolls on this route.
  • Is Knoxville walkable?
    Downtown Knoxville is walkable, but a car is helpful for other areas.
Quick Info
  • From Sumter, South Carolina, United States
  • To Knoxville, Tennessee, United States
  • Modes
Best Time to Travel

Spring or Fall for pleasant weather in Tennessee.

Things to Do in Knoxville
1
Market Square
Explore the vibrant downtown area with shops and restaurants.
2
Sunsphere
Visit the iconic tower from the World's Fair.
3
Sumter County Museum
Enjoy local history in Sumter before you depart.
4
Great Smoky Mountains National Park
Take a short drive to explore the beautiful park.
Tags
Sumter to Knoxville travel driving Sumter to Knoxville I-26 and I-40 travel South Carolina to Tennessee Knoxville travel guide best way to Knoxville travel tips Sumter