No, there is no direct passenger rail service.

How long is the drive?

The drive takes approximately 5.5 hours.

What is the best route?

US-165 to US-65 is the most direct path.

No, there are no toll roads on this route.

No, there are no direct commercial flights available.

Alexandria

Memphis

Driving

Alexandria to Memphis

Updated: 28 May 2026

The drive from Alexandria to Memphis covers about 350 miles. You will head north on US-165 and then transition to US-65, eventually reaching the Mississippi River crossing into Memphis. This route takes approximately 5 hours and 30 minutes. You will pass through the heart of the Mississippi Delta, a region rich in musical history and agricultural heritage.

Total Distance: 560 km driving distance; 480 km straight-line air distance.

Fastest Way

Driving is the fastest method, taking about 5.5 hours.

Cheapest Way

Driving your own vehicle is the most cost-effective option.

Compare Alexandria to Memphis Routes

Driving

Direct

Duration

5 hours 30 mins

Avg Price

50-80 USD

Operator

Personal Vehicle

Route

US-165 N to US-65 N via Greenville and Memphis.

Stop in Greenville for authentic Delta-style tamales.

Travel Tips

Route Planning
US-65 is a scenic route but can be slower than interstate highways.
Traffic
Memphis traffic is generally manageable, but avoid the I-40/I-55 interchange during rush hour.
Rest Stops
Plan your stops in larger towns like Greenville for better facilities.
Navigation
Use GPS to stay on the correct highway as you pass through rural intersections.
Fuel
Fill up in Alexandria before you leave to avoid higher prices in smaller towns.

Safety Tips

Speed Limits
Strictly follow speed limits in small towns along the route.
Wildlife
Be alert for deer and other wildlife on rural roads.
Weather
Check for severe weather alerts, as the region can experience sudden storms.
Vehicle Check
Ensure your vehicle is in good condition for the 5.5-hour drive.