The drive from Altoona to Louisville covers 600 miles, taking you through Illinois and Indiana. You will primarily use I-90 and I-65. The journey takes approximately 9 hours. Louisville is famous for the Kentucky Derby and its bourbon distilleries. This route is relatively flat and easy to navigate.
Total Distance: 960 km driving, 750 km air.
Consider taking the I-294 bypass to avoid Chicago traffic.
April to June or September to October for mild weather.