The drive from Altoona to St. Louis covers 500 miles, taking you south through Illinois. You will primarily use I-90 and I-55. The journey takes approximately 8 hours. St. Louis is famous for the Gateway Arch and its vibrant blues music scene. This route is relatively flat and easy to navigate.
Total Distance: 800 km driving, 680 km air.
Consider taking the I-355 bypass to avoid Chicago traffic.
April to May or September to October for mild weather.