Is there a train to St. Louis?

No direct Amtrak service exists from Anderson; you must drive to Indianapolis.

How long is the drive?

The drive typically takes 4 hours under normal traffic conditions.

I-70 is generally toll-free between Indiana and St. Louis.

What is the best route?

Taking I-69 S to I-70 W is the most direct path.

Yes, the route is a major interstate highway with frequent service stations.

Anderson

St. Louis

Driving

Anderson to St. Louis

Updated: 28 May 2026

The journey from Anderson to St. Louis covers approximately 400 kilometers primarily via I-70 West. You will pass through Indianapolis and Terre Haute before crossing the Illinois border. Driving is the most practical mode, taking roughly 4 hours depending on traffic near the St. Louis Arch. This route traverses the heart of the Corn Belt, offering flat, efficient highway driving. Expect to pay tolls on specific sections of the Indiana Toll Road if you deviate, though I-70 remains largely toll-free.

Total Distance: 400 km driving distance; 360 km straight-line air distance.

Fastest Way

Driving via I-70 W is the fastest, taking 4 hours.

Cheapest Way

Driving your own vehicle is the most cost-effective method for groups.

Compare Anderson to St. Louis Routes

Driving

Direct

Duration

4 hours

Avg Price

$50-$70 in fuel

Operator

Personal Vehicle

Route

I-69 S to I-70 W through Indianapolis and Effingham.

Avoid rush hour in Indianapolis to save 30 minutes of travel time.

Travel Tips

Traffic
Check the Indiana Department of Transportation website for I-70 construction updates.
Fuel
Fill up in Indiana, as gas prices are often lower than in Illinois.
Parking
Use the parking garages near the Arch for secure, daily-rate vehicle storage.
Navigation
Download offline maps as cellular service can be spotty in rural Illinois.
Rest Stops
Stop in Effingham, Illinois, for a wide variety of dining and fuel options.

Safety Tips

Weather
Be prepared for sudden thunderstorms during summer months.
Fatigue
Take breaks every two hours to avoid highway hypnosis on long stretches.
Emergency
Keep a roadside emergency kit with jumper cables and water in your trunk.
Visibility
Use headlights during heavy rain, which is common in the Midwest.