The drive from Ankeny to Madison is approximately 300 miles and takes about four and a half hours. The most efficient route is taking Interstate 80 East to Interstate 39 North. This journey takes you through the scenic landscapes of eastern Iowa and southern Wisconsin. It is a popular route for students and visitors to the University of Wisconsin. The drive is straightforward and well-maintained.
Total Distance: 480 km driving, 400 km air distance.
Watch for speed traps in small towns along the route.
Summer or early autumn for beautiful weather on the lakes.