Is there a train to St. Louis?

No direct train service exists from Ankeny; you would need to drive to a major hub.

What is the best time to leave?

Early morning to avoid afternoon traffic in St. Louis.

Is St. Louis walkable?

Some areas like downtown and the Central West End are, but a car is generally needed.

Ankeny

St. Louis

Driving

Ankeny to St. Louis

Updated: 28 May 2026

The drive from Ankeny to St. Louis is approximately 350 miles and takes about five and a half hours. The most common route involves taking Interstate 35 South to US-65 South, then connecting to Interstate 70 East. This journey takes you through the heart of Missouri. It is a popular route for weekend getaways and family trips. The drive is relatively straightforward with several interesting stops along the way.

Total Distance: 560 km driving, 480 km air distance.

Fastest Way

Driving via I-35 and I-70 is the fastest, taking about 5.5 hours.

Cheapest Way

Driving is the most economical way to reach St. Louis.

Compare Ankeny to St. Louis Routes

Driving

Direct

Duration

5 hours 30 mins

Avg Price

$60-$80 in fuel

Operator

Personal Vehicle

Route

I-35 S to US-65 S to I-70 E

Be prepared for construction near the St. Louis metro area.

Travel Tips

Traffic
Avoid the I-70 corridor through St. Louis during morning and evening rush hours.
Parking
Use public parking garages downtown; street parking can be limited.
Dining
Try the local St. Louis-style pizza and toasted ravioli.
Navigation
Use a GPS to navigate the complex highway system in St. Louis.
Rest Stops
Plan your stops in larger towns along the route for better facilities.

Safety Tips

Speeding
Watch your speed in small towns along US-65.
Vehicle Check
Ensure your tires are properly inflated for the long highway drive.
Visibility
Use headlights during rain, which is common in the Midwest.
Emergency Kit
Keep a basic emergency kit in your car, including water and snacks.