The drive from Apple Valley to Tucson is a straightforward 650-kilometer journey. You will head south to join I-10 East, which takes you directly through the Sonoran Desert. The drive typically takes about 7 hours depending on traffic in the Los Angeles basin. This route is famous for its dramatic desert landscapes and saguaro cacti.
Total Distance: 650 km driving distance; 580 km air distance.
Avoid driving during peak rush hour in the Inland Empire.
November to March for mild desert temperatures.