The drive from San Luis Obispo to Tucson is approximately 950 kilometers. You will follow US-101 South to I-10 East, crossing through the Mojave and Sonoran Deserts. This journey takes you through Los Angeles and Phoenix. Expect a travel time of 10 to 12 hours depending on traffic. Tucson is a beautiful desert city, so plan for a long day of driving.
Total Distance: 950 km driving, 800 km air distance.
Plan for a stop in Phoenix to break up the drive.
Winter or Spring for mild desert weather.