The distance from San Luis Obispo to Anaheim is approximately 200 miles. The most practical way to travel is by driving via US-101 South and I-5 South, a journey that takes about 3 to 4 hours. Anaheim is famous for being home to Disneyland and the Angel Stadium.
Total Distance: 320 km driving distance; 280 km straight-line air distance.
Expect heavy traffic in the Los Angeles area.
Spring and autumn are the best times to visit Anaheim.