Is I-40 the only way to Knoxville?

It is the primary and most efficient route for travelers.

How long is the drive?

It typically takes 1 hour and 45 minutes.

Are there trains to Knoxville?

No, there is no active passenger rail service to Knoxville.

Yes, the route through the Pigeon River Gorge is very beautiful.

Yes, Greyhound provides service between the two cities.

Asheville

Knoxville

Bus Driving

Asheville to Knoxville

Updated: 30 May 2026

The route from Asheville to Knoxville is a straightforward 115-mile drive along I-40 West. This path takes you through the scenic Great Smoky Mountains, crossing the border from North Carolina into Tennessee. The drive is famous for its mountain vistas, particularly through the Pigeon River Gorge. Most travelers complete this journey in approximately 1 hour and 45 minutes. It is a vital corridor connecting the two major hubs of the Southern Appalachian region.

Total Distance: 185 km driving, 150 km air distance.

Fastest Way

Driving is the fastest way, taking less than 2 hours under normal traffic conditions.

Cheapest Way

Driving your own vehicle is the most cost-effective method for this short distance.

Compare Asheville to Knoxville Routes

	Bus Direct	Driving Direct
Duration	2 hours 30 mins	1 hour 45 mins
Avg Price	$30-$60	$20-$30 in fuel
Operator	Greyhound	Personal Vehicle
Route	Asheville Station to Knoxville Station.	I-40 West through the Great Smoky Mountains.
Tip	Check schedules in advance as daily frequency is limited.	Watch for speed limit changes near the North Carolina/Tennessee border.

Travel Tips

Mountain Driving
The I-40 gorge can be windy; keep both hands on the wheel.
Time Zone
Knoxville is in the Eastern Time Zone, same as Asheville.
Parking
Downtown Knoxville offers several public garages with reasonable hourly rates.
Fuel
Fill up in Asheville, as gas prices can fluctuate near the state line.
Traffic
Expect minor delays near the I-40/I-75 interchange in Knoxville.