Bus services are limited and often require multiple transfers.

What is the best route?

I-59 to I-75 is the standard route.

Yes, it is generally safe for tourists.

Birmingham

Knoxville

Driving

Birmingham to Knoxville

Updated: 28 May 2026

The trip from Birmingham to Knoxville is a straightforward 320-kilometer drive. You will head northeast on I-59 toward Chattanooga, then transition to I-75 North. The route takes you through the scenic Appalachian foothills. It is a popular weekend getaway for those looking to visit the Great Smoky Mountains.

Total Distance: 320 km driving, 270 km air distance.

Fastest Way

Driving is the fastest method, taking less than 4 hours.

Cheapest Way

Driving is the only practical and affordable way to make this trip.

Compare Birmingham to Knoxville Routes

Driving

Direct

Duration

3 hours 30 mins

Avg Price

$40-$60 in fuel

Operator

Personal Vehicle

Route

I-59 North to I-75 North.

The stretch through Chattanooga can be hilly; maintain safe speeds.

Travel Tips

Chattanooga Stop
Stop in Chattanooga for lunch to break up the drive.
Mountain Driving
Be prepared for winding roads if you head into the mountains.
Parking
Downtown Knoxville has several public garages with reasonable rates.
Weather
Check mountain weather reports as they differ from city forecasts.
Traffic
Expect minor delays near the I-59/I-75 interchange.

Safety Tips

Speeding
Police frequently monitor speed limits on I-75.
Wildlife
Be alert for deer crossing the highway in rural sections.
Emergency
Keep a spare tire and jack in good working order.
Visibility
Use fog lights if driving through the mountain passes early in the morning.