The drive from Bishop to Sacramento is approximately 450 kilometers. You will head north on US-395 before turning west on US-50 through South Lake Tahoe. This route takes you over the Sierra Nevada mountains and down into the Central Valley. The journey typically takes 6 to 7 hours. Be prepared for mountain driving conditions, especially in the winter.
Total Distance: 450 km driving distance; 320 km straight-line air distance.
Stop in South Lake Tahoe for lunch and a view of the lake.
Late spring to early autumn for the best road conditions.