The drive from Bishop to San Diego is approximately 600 kilometers. You will head south on US-395, eventually connecting to I-15 South through the Inland Empire. This route takes you through the Mojave Desert and into the coastal region of Southern California. The journey typically takes 7 to 8 hours. Be prepared for heavy traffic as you approach the San Diego area.
Total Distance: 600 km driving distance; 520 km straight-line air distance.
Stop in Temecula for a break and a visit to local wineries.
Spring or Fall for the most comfortable temperatures.