Driving
Bristol to Winston-Salem
Updated: 31 May 2026
The drive from Bristol to Winston-Salem is a 150-mile journey through the Blue Ridge Mountains. You will take US-421 South, with the trip taking approximately 2.5 hours. This route offers a beautiful drive through the mountains of Tennessee and North Carolina.
Total Distance: 241 km driving distance, 190 km straight-line air distance.
Fastest Way
Driving via US-421 is the fastest, taking 2.5 hours.
Cheapest Way
Driving your own vehicle is the most cost-effective option.
Compare Bristol to Winston-Salem Routes
Driving
Direct
Duration
2 hours 30 mins
Avg Price
30-40 USD
Operator
Personal Vehicle
Route
US-421 South.
US-421 is a winding mountain road; drive carefully.
Travel Tips
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TrafficAvoid Winston-Salem rush hour traffic.
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NavigationUse GPS to navigate through the mountains.
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ParkingDowntown Winston-Salem has many parking garages.
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DiningTry local North Carolina barbecue.
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WeatherCheck the forecast for mountain weather.
Safety Tips
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Winding RoadsUS-421 has many curves; drive at a safe speed.
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SpeedingFollow the speed limits in North Carolina.
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Vehicle SafetyCheck your brakes before the trip.
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EmergencyKeep a roadside emergency kit in your car.
People Also Ask
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Is there a train to Winston-Salem?No, there is no direct passenger rail service from Bristol.
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How long is the drive?The drive takes about 2.5 hours.
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Are there tolls?No, the route is toll-free.
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Is it a safe route?Yes, it is a major interstate highway.
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Can I fly?There are no direct commercial flights between Bristol and Winston-Salem.
Quick Info
- From Bristol, Tennessee, United States
- To Winston-Salem, North Carolina, United States
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Modes
Best Time to Travel
Spring or Fall for the best scenery.
Things to Do in Winston-Salem
1
Old Salem Museums & Gardens
Visit the historic village.
2
Reynolda House Museum of American Art
Explore the art collection.
3
SciWorks
Visit the science museum.
4
Bethabara Park
Enjoy the historic park.
Tags
Bristol to Winston-Salem drive
US-421 route
Winston-Salem travel guide
Bristol TN to Winston-Salem NC
driving to Winston-Salem
fastest way to Winston-Salem
North Carolina road trip
Winston-Salem attractions
