The drive from Cashiers to Charleston is a 280-mile journey taking approximately 5 hours. You will travel via US-64 E to I-26 E. This route takes you from the mountains to the coast of South Carolina. It is a popular route for those traveling to Charleston for tourism and history. Expect heavy traffic as you approach the Charleston metropolitan area.
Total Distance: 450 km driving distance; 380 km straight-line air distance.
Stop in Columbia for a break to enjoy the city.
Spring or Fall for pleasant weather.