No, there is no direct train from Cashiers to Knoxville.

How long is the drive?

The drive takes about 2 hours and 30 minutes.

Yes, it can be busy in the park.

No, you must drive to a major airport first.

What is the best route?

US-64 to US-441 is the standard route.

Cashiers

Knoxville

Driving

Cashiers to Knoxville

Updated: 28 May 2026

The drive from Cashiers to Knoxville is a 110-mile journey taking approximately 2 hours and 30 minutes. You will travel via US-64 W to US-441 N through the Great Smoky Mountains National Park. This route is incredibly scenic. It is a popular route for those traveling to Knoxville for university events or business. Expect heavy traffic as you approach the Knoxville metropolitan area.

Total Distance: 180 km driving distance; 130 km straight-line air distance.

Fastest Way

Driving via US-441 N is the fastest route, taking 2 hours and 30 minutes.

Cheapest Way

Driving your own car is the most practical and cost-effective method.

Compare Cashiers to Knoxville Routes

Driving

Direct

Duration

2 hours 30 mins

Avg Price

25-35 USD

Operator

Personal Vehicle

Route

US-64 W to US-441 N.

Stop in Gatlinburg for a break to enjoy the views.

Travel Tips

Traffic
US-441 can be very busy in the park; check traffic before you leave.
Parking
Use parking garages in the city center for convenience.
Dining
Knoxville has a great food scene; try the local restaurants.
Navigation
Use a GPS to navigate the city's highway interchanges.
Safety
Stay in well-lit areas when exploring the city at night.

Safety Tips

Highway Safety
US-441 is a winding mountain road; stay alert and follow speed limits.
City Driving
Be aware of one-way streets in downtown Knoxville.
Emergency
Keep your car's maintenance up to date for the long drive.
Awareness
Stay alert in busy urban areas.