The drive from Cashiers to Jacksonville covers approximately 450 miles. You will travel through South Carolina and Georgia before entering Florida. The most direct route involves taking I-95 South. The journey takes about 7 hours of driving time. This route takes you to the Atlantic coast of Florida.
Total Distance: 724 km driving distance, 600 km straight-line air distance.
Plan for a stop in Savannah to break up the drive.
October to April for pleasant weather.