The drive from Cashiers to Tampa covers approximately 650 miles. You will travel through South Carolina and Georgia before entering Florida. The most direct route involves taking I-75 South. The journey takes about 10 hours of driving time. This route takes you to the Gulf Coast of Florida.
Total Distance: 1046 km driving distance, 850 km straight-line air distance.
Plan for a stop in Atlanta or Valdosta to break up the drive.
October to April for pleasant weather.