The drive from Charles Town to Louisville is about 700 kilometers. You will head west on I-70 and then west on I-64. This route takes you through the heart of Maryland, Pennsylvania, and into Kentucky. Expect a travel time of 8 hours. Louisville is a major city known for its horse racing and bourbon.
Total Distance: 700 km driving, 600 km air distance.
I-64 can be very busy; check traffic before you leave.
Spring and autumn for the pleasant weather.