How long is the drive?

The drive takes about 4.5 hours.

Is there a direct train?

Yes, the Amtrak Lincoln Service runs directly from Chicago to St. Louis.

What is the best way to travel?

The train is a comfortable and stress-free option.

Yes, there are several toll roads on the I-55 corridor.

St. Louis is generally safe, but exercise caution in crowded areas.

Cicero

St. Louis

Train Driving

Cicero to St. Louis

Updated: 28 May 2026

The journey from Cicero to St. Louis covers approximately 300 miles. You can drive via I-55 South, which takes about 4.5 hours, or take an Amtrak train from Chicago's Union Station. St. Louis is a historic city known for its iconic Gateway Arch, culture, and food. The route takes you through the heart of the Midwest. Both driving and rail are viable options.

Total Distance: 480 km driving distance, 420 km straight-line air distance.

Fastest Way

Driving is the fastest method, taking about 4.5 hours.

Cheapest Way

Driving is generally the cheapest option for groups.

Compare Cicero to St. Louis Routes

	Train Direct	Driving Direct
Duration	5 hours 30 mins	4 hours 30 mins
Avg Price	$40-$80	$50-$80 in fuel
Operator	Amtrak (Lincoln Service)	Personal Vehicle
Route	Chicago Union Station to St. Louis Gateway Station.	I-55 South all the way to St. Louis.
Tip	The train is a comfortable and scenic way to travel.	I-55 is a straightforward route with minimal traffic outside of Chicago.

Travel Tips

Public Transit
The MetroLink light rail system is the fastest and most efficient way to get around the city.
Walking
The downtown area is very walkable, especially around the Gateway Arch.
Dining
Try the local barbecue and toasted ravioli.
Safety
Stay aware of your surroundings, especially in crowded areas.
Events
Check for cultural events and festivals.