The drive from Columbus to Indianapolis is approximately 45 miles. You will take I-65 North for the entire trip. This is a very straightforward commute that typically takes 50 minutes. Indianapolis is the state capital and a major hub for business and entertainment.
Total Distance: 72 km driving, 65 km straight-line.
Traffic can be heavy near the I-465 interchange.
Any time, but avoid morning and evening rush hours in Indianapolis.