The drive from Danville to Cincinnati is approximately 400 miles. You will travel north through Virginia, West Virginia, and Ohio. The most direct route involves taking US-220 N and I-77 N to I-71 N. This journey takes you through the heart of the Appalachian Mountains. Expect a drive time of about 7 to 8 hours depending on traffic and road conditions.
Total Distance: Driving distance 650 km, straight-line air distance 500 km.
Be prepared for winding roads in the mountains.
April to June or September to October for pleasant weather.