Durham
Durham
Charleston
Charleston
Driving

Durham to Charleston

Updated: 28 May 2026

The trip from Durham to Charleston is a 280-mile journey along the I-95 corridor. The drive takes about 4.5 hours. This is a major transit route connecting North Carolina and South Carolina. Charleston is a historic city with numerous attractions.

Total Distance: 450 km driving, 380 km air distance.
Fastest Way
Driving via I-95 is the fastest route, taking about 4.5 hours.
Cheapest Way
Driving your own vehicle is the most economical way to reach Charleston.
Compare Durham to Charleston Routes
Driving
Direct
Duration
4 hours 30 mins
Avg Price
$50-$80 in fuel
Operator
Personal Vehicle
Route
I-95 S.

I-95 is very busy; check traffic before leaving.

Travel Tips
  • Traffic
    Expect heavy traffic on I-95 during morning and evening rush hours.
  • Parking
    Use the public parking garages in downtown Charleston.
  • Dining
    Try the local restaurants in the French Quarter neighborhood.
  • Navigation
    Use GPS to navigate around construction on I-95.
  • Events
    Check for local events at the Gaillard Center.
Safety Tips
  • Highway Safety
    Stay alert for aggressive drivers on I-95.
  • Weather
    Be aware of heavy rain during the summer months.
  • Sun Safety
    Use sunscreen, as the SC sun can be strong.
  • Emergency
    Keep a charged phone and emergency kit in your car.
People Also Ask
  • Is there a bus?
    Yes, regional bus services connect Durham and Charleston.
  • How long is the drive?
    It takes approximately 4 hours and 30 minutes.
  • Are there tolls?
    No, this specific route is toll-free.
  • What is the best route?
    Taking I-95 South is the most direct path.
  • Can I take a train?
    Yes, Amtrak offers service between Durham and Charleston.
Quick Info
  • From Durham, North Carolina, United States
  • To Charleston, South Carolina, United States
  • Modes
Best Time to Travel

Spring and fall for pleasant weather.

Things to Do in Charleston
1
The Battery
Explore this historic waterfront area featuring beautiful homes and parks.
2
Charleston City Market
Visit this historic market featuring a wide variety of local goods.
3
South Carolina Aquarium
Explore this massive aquarium featuring a wide variety of marine life.
4
Rainbow Row
Visit this iconic street featuring colorful historic homes.
Tags
Durham to Charleston drive NC to SC travel I-95 route Charleston travel guide Durham to Charleston distance road trip I-95 travel Charleston transport