Amtrak has a station in Durham, but no direct line from Hilton Head.

How long is the drive?

The drive takes about 5.5 hours.

No, the primary route is toll-free.

What is the best route?

I-95 North to I-40 West and I-85 North is the standard route.

Yes, it is a standard interstate route with plenty of services.

Hilton Head Island

Durham

Driving

Hilton Head Island to Durham

Updated: 28 May 2026

The journey from Hilton Head Island to Durham covers roughly 340 miles. You will primarily use I-95 North and I-40 West to reach the Research Triangle area. The drive typically takes 5 hours and 30 minutes. You will pass through major cities like Fayetteville before reaching Durham. The route is well-serviced with gas stations and restaurants. It is a common route for students and professionals traveling to the area.

Total Distance: 547 km driving distance; 475 km straight-line air distance.

Fastest Way

Driving via I-95 and I-40 is the fastest method, taking about 5.5 hours.

Cheapest Way

Driving your own car is the most cost-effective way to reach Durham.

Compare Hilton Head Island to Durham Routes

Driving

Direct

Duration

5 hours 30 mins

Avg Price

$65-$90 in fuel

Operator

Personal Vehicle

Route

I-95 North to I-40 West, then I-85 North to Durham.

Traffic around the I-40/I-85 interchange can be heavy; stay in the correct lane.

Travel Tips

Traffic
Durham is part of the Research Triangle; expect heavy traffic during morning and evening commutes.
Parking
Downtown Durham has several public parking decks that are reasonably priced.
Rest Stops
Plan a stop in Smithfield, NC, for a variety of food and fuel options.
Navigation
Use a real-time traffic app to navigate around potential accidents on I-85.
Dining
Durham has a world-class food scene; research restaurants in the American Tobacco Campus area.

Safety Tips

Speeding
Local police are active on the highways leading into Durham; watch your speed.
Weather
Be prepared for sudden summer thunderstorms that can reduce visibility.
Vehicle Maintenance
Ensure your car is serviced before this long drive to avoid breakdowns.
Emergency Kit
Keep a basic emergency kit in your trunk at all times.