The trip from Frederick to Norfolk is about 300 kilometers and takes 3.5 hours by car. You will travel south on I-95 and then east on I-64 toward Norfolk. This is a popular route for those visiting the coastal city. Public transit options are available, but driving is the most common method for this route.
Total Distance: 300 km driving, 260 km air distance.
I-95 and I-64 can be very congested; use real-time traffic apps.
Anytime, but avoid rush hour for a smoother trip.