The trip from Frederick to Pittsburgh is about 280 kilometers and takes 3 hours by car. You will travel west on I-70 and then north on I-76 toward Pittsburgh. This is a popular route for those visiting the city. Public transit options are available, but driving is the most common method for this route.
Total Distance: 280 km driving, 240 km air distance.
I-76 is a toll road; have your E-ZPass ready.
Anytime, but avoid rush hour for a smoother trip.