Gainesville
Gainesville
Birmingham
Birmingham
Flight Driving

Gainesville to Birmingham

Updated: 28 May 2026

The journey from Gainesville, Missouri to Birmingham, Alabama covers roughly 600 miles. You will head south through Memphis and then east via I-22. Driving is a 9-hour trip. Alternatively, fly from Springfield-Branson National Airport to Birmingham-Shuttlesworth International Airport. This route takes you from the Ozarks to the heart of the Deep South.

Total Distance: 950 km driving, 750 km air distance.
Fastest Way
Flying from SGF to BHM takes 4 hours including the connection.
Cheapest Way
Driving is the most cost-effective method for this distance.
Compare Gainesville to Birmingham Routes
Flight
Connecting
Driving
Direct
Duration 4 hours 9 hours
Avg Price $250-$450 $100-$150 in fuel
Operator American Airlines Personal Vehicle
Route SGF to BHM via Charlotte or Dallas. US-63 to I-55 South through Memphis, then I-22 East to Birmingham.
Tip American Airlines offers the most frequent connections. The drive is straightforward; plan for a stop in Memphis.
Travel Tips
  • Dining
    Try local specialties like Southern barbecue and soul food.
  • Transportation
    A car is recommended for exploring the city and surrounding areas.
  • Weather
    Birmingham can have hot, humid summers and mild winters; pack accordingly.
  • Safety
    Birmingham is generally safe, but stay aware of your surroundings in downtown at night.
  • Events
    Check for local festivals like the Birmingham Artwalk.
Safety Tips
  • Driving
    I-22 can be busy; stay alert for traffic in Memphis and Birmingham.
  • Emergency
    Keep your phone charged for GPS navigation.
  • Weather
    Alabama can have severe thunderstorms in spring; check forecasts.
  • General Safety
    Stick to well-lit, populated areas when exploring at night.
People Also Ask
  • Is there a train to Birmingham?
    Amtrak's Crescent line stops in Birmingham, but you must reach a hub to board.
  • How long is the drive?
    Approximately 9 hours of driving time.
  • What is the best airport?
    Birmingham-Shuttlesworth International Airport (BHM).
  • Are there tolls?
    No major tolls on this route.
  • Is it safe to drive?
    Yes, the route follows major interstates and is very safe.
Quick Info
  • From Gainesville, Missouri, United States
  • To Birmingham, Alabama, United States
  • Modes
Best Time to Travel

April to May or September to October for pleasant weather.

Things to Do in Birmingham
1
Birmingham Civil Rights Institute
A powerful museum dedicated to the history of the Civil Rights Movement.
2
Barber Vintage Motorsports Museum
A world-class museum featuring an extensive collection of motorcycles and cars.
3
Birmingham Botanical Gardens
A beautiful garden with a wide variety of plants and flowers.
4
Sloss Furnaces National Historic Landmark
A former iron furnace turned into a unique museum and event space.
Tags
Gainesville to Birmingham travel driving Missouri to Alabama flights SGF to BHM I-22 road trip best way to Birmingham Southern travel Gainesville MO transit Birmingham city guide