The distance from Gainesville, MO to Los Angeles is 2,800 kilometers. The most practical way to travel is to drive to Springfield-Branson National Airport (SGF) and fly to Los Angeles International Airport (LAX). The trip takes about 6 hours with a connection. Driving would take over 28 hours.
Total Distance: 2,800 km driving, 2,500 km air distance.
Look for flights connecting through Dallas or Denver.
March to May or September to November for mild weather.