Greenville
Greenville
San Antonio
San Antonio
Flight Driving

Greenville to San Antonio

Updated: 28 May 2026

The journey from Greenville to San Antonio is approximately 1,000 km. Driving takes about 10 hours via US-82 W and I-45 S. You will pass through the scenic landscapes of Louisiana and Texas. Alternatively, you can fly from Greenville Mid-Delta Airport (GLH) to San Antonio International Airport (SAT) with a connection. This route offers a transition from the Mississippi Delta to the historic city of San Antonio.

Total Distance: 1,000 km driving, 850 km air distance.
Fastest Way
Flight from Greenville (GLH) to San Antonio (SAT) takes about 5 hours including the connection.
Cheapest Way
Driving is the most cost-effective option for this distance.
Compare Greenville to San Antonio Routes
Flight
Connecting
Driving
Direct
Duration 5 hours 10 hours
Avg Price $300 - $600 $150 - $250 in fuel
Operator American Airlines Personal Vehicle
Route GLH to SAT via Dallas. US-82 W to I-45 S and I-10 W.
Tip Flights are limited; book well in advance. The drive through Texas is long; stop in Dallas to break it up.
Travel Tips
  • Traffic
    Expect heavy traffic in downtown San Antonio during rush hours.
  • Dining
    Try the famous Tex-Mex food at a local restaurant.
  • Navigation
    Download offline maps for the remote stretches of Texas.
  • Airport
    SAT is well-connected to the city via shuttle and taxi.
  • Weather
    Be prepared for hot and humid summers.
Safety Tips
  • Fatigue
    Take regular breaks on the long, flat stretches of I-10.
  • Vehicle Check
    Ensure your cooling system is in top shape for the summer heat.
  • Urban Safety
    Stay in well-lit areas when walking in downtown San Antonio at night.
  • Emergency Prep
    Carry extra water and snacks in your vehicle.
People Also Ask
  • Is there a direct flight?
    No, all flights from Greenville require at least one connection.
  • How long is the drive?
    The drive takes approximately 10 hours of pure road time.
  • What is the best way to get around San Antonio?
    A car is recommended for getting around San Antonio.
  • Are there tolls in San Antonio?
    Yes, there are some toll roads in the area.
  • Can I take a train?
    Amtrak serves San Antonio, but there is no rail service from Greenville.
Quick Info
  • From Greenville, Mississippi, United States
  • To San Antonio, Texas, United States
  • Modes
Best Time to Travel

March to May or September to November for mild weather.

Things to Do in San Antonio
1
The Alamo
Visit the historic mission and fortress in the heart of San Antonio. It is a must-see.
2
River Walk
Explore the beautiful river walk lined with shops and restaurants.
3
Greenville History
Learn about the history of Greenville before you depart.
4
San Antonio Missions
Visit the historic missions in the city.
Tags
Greenville to San Antonio flights to San Antonio from Mississippi driving Greenville to San Antonio traveling to Texas Southern road trip best way to San Antonio Greenville travel