There is no passenger train service to Greenville.

How long is the drive?

The drive takes approximately 4 hours.

What is the best route?

US-49 to US-82 is the most efficient route.

There are no tolls on this route.

Yes, it is a standard highway route.

Hattiesburg

Greenville

Driving

Hattiesburg to Greenville

Updated: 28 May 2026

The drive from Hattiesburg to Greenville takes about 4 hours and covers 320 kilometers. You will travel north on US-49 through Jackson, then head west on US-82 into the Mississippi Delta. This route takes you through the heart of the Delta, known for its rich agricultural history and blues music heritage. It is a straightforward drive on well-maintained state and federal highways.

Total Distance: 320 km driving distance; 290 km straight-line air distance.

Fastest Way

Driving is the fastest method, taking 4 hours.

Cheapest Way

Driving your own vehicle is the most practical and cheapest way to travel.

Compare Hattiesburg to Greenville Routes

Driving

Direct

Duration

4 hours

Avg Price

$50-$70 in fuel

Operator

Personal Vehicle

Route

US-49 N to US-82 W.

US-82 is a major artery; watch for agricultural machinery.

Travel Tips

Delta Driving
Be prepared for flat, open roads; keep your speed consistent.
Dining
Greenville is famous for its hot tamales; try a local restaurant.
Planning
Check for local festivals, as Greenville hosts several throughout the year.
Navigation
Use a GPS to navigate the turns in the Delta region.
Parking
Parking is generally easy to find in downtown Greenville.

Safety Tips

Agricultural Traffic
Watch for slow-moving tractors on rural roads.
Weather
The Delta can be prone to flooding; check road conditions during heavy rain.
Fatigue
Take breaks to stay alert on the long, straight stretches of road.
Emergency
Keep a basic emergency kit in your car.