The drive from Hammond to Knoxville is a long 1050-kilometer journey. You will head north on I-55, then east on I-40 through Memphis and Nashville. The drive takes approximately 10.5 hours. This route takes you across the entire state of Tennessee, ending in the beautiful foothills of the Great Smoky Mountains.
Total Distance: 1050 km driving, 920 km air distance.
Plan for an overnight stop in Nashville.
Autumn for the fall foliage in the mountains.