Driving
Hatteras to Winston-Salem
Updated: 28 May 2026
The drive from Hatteras to Winston-Salem covers 350 miles. You will travel north on NC-12, west on US-64, and merge onto I-40 West. This route takes you through the heart of North Carolina. The drive takes approximately 6 hours. You will transition from the coastal islands to the historic city of Winston-Salem.
Total Distance: 563 km driving distance, 430 km air distance.
Fastest Way
Driving is the only practical method, taking 6 hours.
Cheapest Way
Driving your own vehicle is the most economical option.
Compare Hatteras to Winston-Salem Routes
Driving
Direct
Duration
6 hours
Avg Price
65-75 USD
Operator
Personal Vehicle
Route
NC-12 to US-64 West to I-40 West.
Stop in Greensboro for a break.
Travel Tips
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TrafficI-40 can be busy; check traffic reports before leaving.
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Rest StopsUse the rest areas on I-40 for quick breaks.
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FuelFill up in the Raleigh area to save money.
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NavigationUse a GPS to navigate the city streets of Winston-Salem.
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DiningTry the local restaurants in downtown Winston-Salem.
Safety Tips
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SpeedingI-40 is heavily patrolled; stay within the speed limit.
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FatigueTake breaks to avoid driver fatigue on this long trip.
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WeatherBe aware of potential thunderstorms in the summer.
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EmergencyKeep a basic emergency kit in your car.
People Also Ask
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How long is the drive to Winston-Salem?The drive takes approximately 6 hours.
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Is there a train?No, there is no direct train from Hatteras.
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Are there tolls?No, the route is toll-free.
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Can I fly?You can drive to RDU and fly, but driving is usually faster.
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What is the best route?US-64 West to I-40 West is the most direct.
Quick Info
- From Hatteras, North Carolina, United States
- To Winston-Salem, North Carolina, United States
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Modes
Best Time to Travel
Spring is lovely in Winston-Salem with many blooming gardens.
Things to Do in Winston-Salem
1
Old Salem
Visit this historic Moravian town. It features restored buildings and living history demonstrations.
2
Reynolda House
Explore the historic estate and art museum. It is a beautiful example of early 20th-century architecture.
3
SciWorks
Enjoy interactive science exhibits and a planetarium. It is great for families.
4
Salem Lake
Relax by the lake or go for a walk on the trails. It is a peaceful spot near the city.
Tags
Hatteras to Winston-Salem
driving to Winston-Salem
Outer Banks to Winston-Salem
NC-12 to I-40
travel to Winston-Salem
Hatteras road trip
Winston-Salem directions
NC travel
