The drive from Hattiesburg to Huntsville takes about 5 hours and covers 450 kilometers. You will travel north on I-59 to Birmingham, then north on I-65 into Huntsville. This route takes you through the heart of Mississippi and Alabama. It is a straightforward drive on major interstate highways. Huntsville is known for its space history, museums, and cultural attractions.
Total Distance: 450 km driving distance; 400 km straight-line air distance.
Traffic in Birmingham and Huntsville can be heavy; plan accordingly.
Spring and Autumn are best for outdoor activities in Huntsville.