The route from Hattiesburg to Little Rock spans roughly 550 kilometers. You will travel north on US-49 through Jackson, Mississippi, before connecting to I-40 West in Arkansas. This journey takes you through the heart of the Mississippi Delta and across the Mississippi River. Expect a mix of rural highways and major interstate travel. The drive typically takes 6 hours without significant stops.
Total Distance: 550 km driving distance; 480 km straight-line air distance.
Watch for speed traps in small towns along US-49.
Autumn is ideal for the drive, as the foliage in the Delta is vibrant and temperatures are cool.