There is no passenger train service to Tupelo.

How long is the drive?

The drive takes approximately 4 hours.

What is the best route?

US-49 to I-55 to I-22 is the most efficient route.

There are no tolls on this route.

Yes, it is a standard highway route.

Hattiesburg

Tupelo

Driving

Hattiesburg to Tupelo

Updated: 28 May 2026

The journey from Hattiesburg to Tupelo covers approximately 350 kilometers and takes about 4 hours. You will travel north on US-49, then transition to I-55 and eventually US-78/I-22. This route takes you through the center of Mississippi, passing near Jackson and heading into the rolling hills of the north. It is a popular route for those visiting the Elvis Presley Birthplace and Museum.

Total Distance: 350 km driving distance; 310 km straight-line air distance.

Fastest Way

Driving is the fastest method, taking 4 hours.

Cheapest Way

Driving your own vehicle is the most practical and cheapest way to travel.

Compare Hattiesburg to Tupelo Routes

Driving

Direct

Duration

4 hours

Avg Price

$50-$70 in fuel

Operator

Personal Vehicle

Route

US-49 N to I-55 N to I-22 E.

The transition to I-22 is well-marked; stay alert for highway signs.

Travel Tips

Rest Stops
Stop in Jackson or Grenada for food and fuel breaks.
Route Choice
I-22 is a modern highway that makes the final leg of the trip very smooth.
Planning
Check the museum hours for the Elvis Birthplace before you arrive.
Navigation
Use a GPS to navigate the transition between the different highways.
Parking
Parking is free and abundant at most tourist attractions in Tupelo.

Safety Tips

Speed Limits
Be aware of speed limit changes on I-22.
Weather
Check for severe weather alerts, as North Mississippi can experience storms.
Fatigue
Take a break at the halfway point to stay refreshed.
Emergency
Keep a spare tire and jack in your vehicle.