The drive from Hyannis to Philadelphia covers 450 kilometers. You will head west on Route 6, then take I-495 to I-95 South, passing through Rhode Island, Connecticut, and New York. The trip takes about five hours, though traffic in the New York City area can be significant. It is a major corridor along the East Coast. Philadelphia is a historic city with much to offer.
Total Distance: 450 km driving, 380 km air distance.
Avoid the New York City area during rush hour to save time.
Spring or Fall for comfortable weather to walk around the historic district.