The drive from Hyannis to Portland, Maine, covers 250 kilometers. You will head north on Route 6, then take I-495 to I-95 North, passing through Boston and the New Hampshire coast. The trip takes about three hours, though traffic around Boston can be significant. It is a beautiful drive that takes you through the heart of New England. Portland is a vibrant coastal city known for its food scene.
Total Distance: 250 km driving, 210 km air distance.
Avoid Boston during rush hour to save significant time.
Summer for the best weather to enjoy the Portland waterfront and harbor tours.