Is there a direct train?

No, there is no direct Amtrak service between Independence, Ohio and St. Louis.

How long is the drive?

The drive takes approximately 6 hours under normal traffic conditions.

What is the best route?

Taking I-71 South to I-70 West is the most efficient path.

There are no major toll roads on the primary I-70 route.

Indianapolis is the ideal midpoint for a meal or rest stop.

Independence

St. Louis

Flight Driving

Independence to St. Louis

Updated: 28 May 2026

The journey from Independence, Ohio to St. Louis covers approximately 600 kilometers. Most travelers prefer driving via I-71 South to I-70 West for a direct route. Alternatively, you can fly from Cleveland Hopkins International Airport to St. Louis Lambert International Airport. The drive typically takes 6 hours depending on traffic near Columbus and Indianapolis. This route crosses the heart of the Midwest, offering scenic views of the Ohio River Valley and rolling plains. Plan your departure to avoid rush hour in major metropolitan hubs.

Total Distance: 600 km driving, 540 km air distance.

Fastest Way

Flying is faster but requires airport security time and layovers.

Cheapest Way

Driving is the most cost-effective method for groups or families.

Compare Independence to St. Louis Routes

	Flight Connecting	Driving Direct
Duration	3 hours 30 mins	6 hours
Avg Price	$250-$400	$70-$100 in fuel
Operator	United Airlines	Personal Vehicle
Route	CLE to STL via Chicago O'Hare.	I-71 S to I-70 W through Columbus and Indianapolis.
Tip	Book at least three weeks in advance to secure lower fares.	Stop in Indianapolis for a quick break at the White River State Park.

Travel Tips

Traffic Avoidance
Avoid passing through Indianapolis during weekday morning and evening rush hours.
Fuel Stops
Refuel in Ohio or Missouri to take advantage of lower state gas taxes compared to Indiana.
Parking
Use the Gateway Arch parking garage for convenient access to downtown attractions.
Weather Check
Monitor winter weather reports for I-70, as snow can cause significant delays.
Hydration
Keep water in your vehicle for the long stretch across the flat plains of Indiana and Illinois.

Safety Tips

Road Fatigue
Switch drivers every three hours to maintain alertness on the monotonous stretches of I-70.
Emergency Kit
Carry a basic roadside kit including jumper cables and a flashlight.
Night Driving
Be cautious of deer crossings in rural sections of Illinois at night.
Vehicle Check
Ensure your tire pressure is optimal before starting this long-distance drive.