The drive from Jefferson to Indianapolis is approximately 850 kilometers. You will head north on I-75 to Lexington, then take I-64 West to I-65 North into Indianapolis. This journey takes about 9 hours. You will traverse the heart of the Midwest, passing through Kentucky and into Indiana.
Total Distance: 850 km driving distance; 760 km straight-line air distance.
The route through Louisville can be busy; plan accordingly.
May for the Indy 500 or September for mild weather.