The drive from Jefferson to Kansas City is approximately 1,300 kilometers. You will head north on I-75 to Nashville, then take I-24 to I-57 and I-70 West into Kansas City. This journey takes about 14 hours. You will traverse several states, including Tennessee, Kentucky, Illinois, and Missouri.
Total Distance: 1,300 km driving distance; 1,150 km straight-line air distance.
This is a long drive; plan for an overnight stop.
May to June or September to October for mild weather.