Traveling from Jefferson to Memphis covers roughly 600 kilometers. The most efficient route involves taking I-85 South to Atlanta, then I-75 North to Birmingham, and finally I-22 West directly into Memphis. This drive takes approximately 6 hours of pure road time. You will cross the Appalachian foothills and enter the Mississippi Delta region. It is a straightforward interstate drive suitable for a single-day trip.
Total Distance: 600 km driving distance; 540 km straight-line air distance.
I-22 is a modern highway with fewer stops; fuel up in Birmingham.
April to June for pleasant temperatures and outdoor music festivals.