The trip from Johnson City to Knoxville is a straightforward drive through the scenic hills of East Tennessee. The most practical mode is driving via I-81 South, which merges into I-40 West. The journey covers approximately 170 kilometers and takes about two hours. Knoxville is a vibrant university town and the gateway to the Great Smoky Mountains.
Total Distance: Driving distance 170 km, straight-line air distance 140 km.
Traffic can be heavy near the I-40/I-81 interchange.
Autumn for the fall foliage or spring for blooming flowers.