The drive from Lander to Oklahoma City covers approximately 1,450 kilometers. You will head east on WY-220 to I-25, then travel south through Colorado and Kansas before heading east on I-35 to Oklahoma City. This route takes roughly 14 hours of driving time. You will pass through the scenic landscapes of the Rocky Mountain foothills and the Oklahoma plains.
Total Distance: 1,450 km driving distance; 1,250 km straight-line air distance.
Stop in Wichita, Kansas, for a mid-trip break.
Late spring or early autumn for comfortable driving weather.