Traveling from Largo to Fort Lauderdale is a straightforward 260-mile journey across the Florida peninsula. Most travelers take I-75 South to I-595 East for the most direct path. The route takes you through the scenic Everglades region. You can also utilize bus services from the Tampa Bay area. Expect a travel time of roughly 4 hours by car.
Total Distance: 420 km driving distance; 350 km straight-line air distance.
Stop in Naples for a quick lunch break.
Winter months offer the most comfortable temperatures for coastal activities.