The trip from Largo to Jacksonville covers roughly 200 miles heading north. You will typically take I-275 N to I-75 N, eventually connecting to I-10 E. This route takes you through the central Florida landscape and into the northern coastal region. The drive takes approximately 3.5 hours under normal conditions. It is a popular route for those heading to the Atlantic coast.
Total Distance: 330 km driving distance; 290 km straight-line air distance.
Stop in Gainesville for a break.
Spring and Fall offer the most pleasant weather for exploring the city.