Traveling from Las Cruces to Tucson covers 275 miles primarily along Interstate 10 West. This route takes you through the high desert of southern New Mexico and into the Sonoran Desert of Arizona. The drive usually takes about four hours, passing through Deming and Lordsburg. You will experience a significant change in flora as you transition from yucca-covered plains to the iconic Saguaro cactus landscapes of Arizona. It is a straightforward drive, but requires preparation for desert heat.
Total Distance: 442 km driving distance; 415 km straight-line air distance.
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Direct
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Direct
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| Duration | 5 hours 30 mins | 4 hours |
| Avg Price | $45-$70 | $50-$75 in fuel |
| Operator | Greyhound | Personal Vehicle |
| Route | Departs from Las Cruces to Tucson Bus Station. | I-10 West through Deming, Lordsburg, and Benson. |
| Tip | Buses often make a short stop in El Paso or Lordsburg. | Ensure your cooling system is in top condition before attempting this drive in summer. |
November to March to avoid the extreme summer heat of the Sonoran Desert.