The drive from Ludington to Columbus covers 500 km and takes about 5 hours. You will take US-131 South to I-96 East, then I-75 South to US-23 South into Ohio. This route is efficient and avoids the worst of the Detroit traffic. Driving is the only practical way to make this trip.
Total Distance: 500 km by road, 430 km straight-line.
US-23 can be busy; stay alert for traffic changes.
Spring or autumn for comfortable driving temperatures.