The drive from Ludington to St. Louis covers 750 km and takes about 8 hours. You will take US-131 South to I-94 West, then I-55 South into St. Louis. This is a long drive that requires careful planning. Driving is the only practical way to make this trip.
Total Distance: 750 km by road, 650 km straight-line.
Plan for multiple stops to stay alert during this long drive.
Spring or autumn for comfortable driving temperatures.